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By admin / July 18, 2015

Simultaneous use of parenteral magnesium sulfate and intravenous

Calcium salts is also used in patients with post-parathyroidectomy

“hungry bones” syndrome or tetany associated with

Hypocalcemia and hypomagnesemia. Oral calcium-containing

Medications may increase serum calcium or magnesium concentrations

In susceptible patients, primarily patients with renal


Administration of oral magnesium salts with cellulose sodium

Phosphate or edetate disodium (EDTA) may result in binding of

Magnesium. Do not administer oral magnesium salts within 1 hour of

Cellulose sodium phosphate or edetate disodium.

Concurrent use of cardiac glycosides with magnesium salts may

Inhibit absorption and possibly decrease plasma concentrations of

Cardiac glycosides. Because cardiac conduction changes and heart

Block may occur magnesium slats must be administered with extreme

Caution in digitalized patients, especially if intravenous calcium

Salts are also used.

Diuretics may interfere with the kidneys ability to regulate

Magnesium concentrations. Long-term use of loop diuretics or

Thiazide diuretics may impair the magnesium-conserving ability of

The kidneys and lead to hypomagnesemia. Conversely, long-term use

Of potassium-sparing diuretics has been found to increase renal

Tubular reabsorption of magnesium which may cause hypermagnesemia

In patients also receiving magnesium supplements, especially in

Patients with renal insufficiency.

Concurrent use of magnesium supplements with other

Magnesium-containing antacids or laxatives may result in magnesium

Toxicity, especially in patients with renal impairment.

Administration of oral magnesium salts with oral tetracyclines or

Quinolone antibiotics may form nonabsorbable complexes resulting

In decreased absorption of tetracyclines and quinolones. Do not

Administer oral magnesium salts within 1—3 hours of taking an

Oral tetracycline or oral fluoroquinolone.

Oral magnesium salts may prevent absorption of oral etidronate. Do

Not administer magnesium salts within 2 hours of oral etidronate.

Clinically significant drug interactions have occured when IV

Magnesium salts were given concurrently with nifedipine during the

Treatment of hypertension or premature labor during pregnancy. The

Women affected presented with either pronounced muscle weakness

And/or hypotension. In a few cases, fetal harm was noted as a

Result of the hypotensive episodes. The effects have been

Attributed to nifedipine potentiation of the neuromuscular

Blocking effects of magnesium. It is recommended that nifedipine

Not be given concurrently with magnesium therapy for pre-eclampsia,