BY THOMAS J. ROMANO MD PHD FACP FACR AND JOHN W. STILLER MD
1 Faculty American Academy of Pain Management–Private Practice, Wheeling, WV
26003, USA; 2 Private Practice, Lakeland, FL 33813, US
Correspondence to: Dr Thomas J. Romano, Suite 201, Center 3, Medical Park,
Wheeling, WV 26003, USA For Mg, UL is intake only from supplements; does not include Mg
In food and water.
For Ca, P, and vitamin D, includes the total intake from food,
Water, and supplements.
How does Magnesium work for
Magnesium is a dietary mineral that helps regulate blood vessel
Size, serotonin function, and nerve activity in the brain, among
Other functions. Magnesium deficiency is thought to be at least
One important factor in migraine attacks. Many studies suggest
That magnesium might be a common denominator in both the vascular
And the neural theories of migraine. In support of the vascular
Theory, magnesium deficiency results in blood vessel constriction
And adding magnesium to the diet leads to the opening (dilation)
Of blood vessels. In support of the neural theory, magnesium
Deficiency has been linked with the production and release of
Substance P12-a biochemical that contributes to the inflammation
Of nerves and headache pain.
In a recent study conducted by Dr Alexander Mauskop and his
Colleagues, they reported an 85% success rate in treating
Migraines with an intravenous injection of magnesium. In the study
85% of the magnesium deficient men and women in the middle of a
Migraine attack experienced rapid and dramatic relief of symptoms
When they received magnesium. Within minutes individuals felt
Relief of migraine pain. They also felt relief from nausea and
From sensitivity to light and noise. Aside from a very few
Patients who had short-term light headedness during the infusion,
There were no side effects. In the study people who were not
Deficient in magnesium at the outset did not experience relief.
This indicates that improvement was not due to a placebo effect.
Recent studies indicate that magnesium depletion, that is, having
Lower than normal levels of the mineral magnesium, can influence
Serotonin and nitric oxide release, blood vessel size, and
Inflammation. It’s also thought that people with mitral valve
Prolapse have lower than normal levels of magnesium.
Several studies have shown that magnesium depletion plays a
Critical role in blood vessel size. It seems not only to cause
Blood vessel constriction but to make blood vessels more sensitive
To other chemicals that cause constriction and less sensitive to
Substances that cause blood vessels to dilate.
Studies have also shown that magnesium depletion seems to help
Release serotonin from its storage sites. It also helps make blood
Vessels in the brain more receptive to serotonin and thus clears
The way for serotonin to cause constriction of blood vessels.