Enteric coated drugs: May be released prematurely
In stomach. Separate doses by at least 1 hour.
Magnesium sulfate can enhance the neuromuscular blocking effects
Of neuromuscular blockers such as d-tubocurarine, and
Succinylcholine. Caution should be exercised when using these
Because of the CNS-depressant effects of magnesium sulfate,
Additive central-depressant effects can occur following concurrent
Administration with barbiturates, opiate agonists, H1-blockers,
Antidepressants, benzodiazepines, general anesthetics, local
Anesthetics, and phenothiazines.
Concurrent use of oral magnesium salts with sodium polystyrene
Sulfonate (Kayexalate®) is not recommended. Sodium polystyrene
Sulfonate may bind with magnesium salts administered orally;
However, the risk of binding with oral magnesium salts may be less
With rectal administration of sodium polystyrene sulfonate.
Excessive ethanol or glucose intake has been found to increase
Urinary excretion of magnesium. Avoid high intakes of ethanol and
Glucose while taking magnesium salts.
Concurrent use of intravenous calcium salts with parenteral
Magnesium sulfate can neutralize the effects of parenteral mgso4;
However, calcium gluconate and calcium gluceptate are used
Clinically to antagonize the toxic effects of hypermagnesemia.